The status of cardiovascular health is regulated by endothelium - the innermost lining (layer) of arteries. The endothelial cells control the elasticity - relaxation and tightening - of blood vessels (the more elastic the arteries, the better).
However, subsequent dysfunction of the endothelium plays a central role in the process of arterial fatty plaque formation, leading to the development of atherosclerosis.
The endothelial function can be measured now. A relatively new test, called FMD - flow mediated dilation, can be done by stopping blood flow to the lower arm with a blood pressure cuff, releasing it, and measuring the blood vessel diameter of an artery with ultrasound.
In the processs of atherosclerosis then, arterial walls - especially the aorta and the coronary arteries serving the heart - become covered with fatty plaques, called atheromas that keep on enlarging.
The Arterial Endothelial Injury
Although arterial plaque formation my be triggered by many factors, they all relate to:
The injury to endothelial cells - the innermost lining (or layer) of an artery, triggers the response of blood cells called platelets to accumulate at the site of injury, in an effort to plug the damaged area.
The sticking together platelets secrete a growth factor that stimulates the outgrowth of underlaying endothelial cells. These cells then begin to protrude into the arterial wall.
Through specific receptors, the outgrown endothelial cells:
- ingest lipoprotein particles and
- accumulate cholesterol and triacylglyceroles (triglycerides), transforming themselves into plaque - fat-engorged foam cells.
Finally, connective tissue penetrates the plaque, which in advanced situations can become calcified and, consequently, add rigidity to the blockage (occlusion).
Atherosclerotic plaque formation is an overly aggressive homeostatic process in order to correct and balance the condition triggered by the arterial endothelial injury. This process occurs as long as there is a presence of platelet accumulation function.
There is one kind of harmful, oxidative agents of significant importance that initiate the endothelial injury leading to atherial plaque formation, called free radicals.
Oxidative Free Radical Damage
Free radicals, also called reactive oxygen species (ROS), are highly unstable molecular fragments - both of internal and external origin. They are being constantly released in the body, whenever we are exposed to harmful, both dietary and environmental factors, such as
The more free radicals are created in the body, the more damage is done on the cellular level - to the bodily cells due to a multitude spark-like reactions.
Many of free radicals, such as viscious free hydroxy radicals, are a severe threat to our system as they attack:
- cellular membranes and tissues in the body
- our genetic material (mainly DNA)
- proteins and enzymes, and
- polyunsaturated fatty acids, thus, heightening the inflammatory processes in the cells.
To make things worse, an extensive free radical damage generates other, even more destructive free radicals, creating a classical vicious cycle.
Free radical-induced changes lead to mutations or even breakages, or injuries on the cellular level - such as endothelial injury - which, if not repaired, result in a variety of serious diseases, including atherosclerosis - a degenerative condition of arterial vessels.
Unfortunately, over the years, as our exposure to free radicals in our everyday life has been steadily increasing, their production has become excessive and uncontrolled, resulting in the reduced ability of our immune system to protect us from their damage.
In other words, most of the time, our natural ability of keeping them under control is impaired - insuffcient or even absent.
However, in order to prevent further damage (and sustaine life), that cascade of unwanted, free radical-induced changes needs to be controlled and, eventually, halted. For this reason some free radicals generated must be neutralized - and removed from the body.
Generally speaking, it can be done in two ways:
- externally, by reducing our exposure to them, and
- internally, by increasing the activity of antioxidants in the body.
The Antioxidant Response
As our cardiosvascular system is highly susceptible to free radical damage, antioxidants are of incredible help here. By neutralizing and "mopping up" free radicals in the body, antioxidants play a key role in slowing down the process of atheromatous plaque formation.
Our body has a whole, built-in, internal free-radical scavenging system, consisting of such powerful antioxidants as:
- uric acid (in aqueous solutions)
- an enzyme SOD (superoxide dismutase), activated by zinc, copper and manganese; and
- glutathione peroxidase, an enzyme activated by selenium. (In addition to selenium, glutathione peroxidase requires the presence of other nutrients, such as L-glycine, L-cysteine, lipoic acid, methionine, and glutamic acid; deficiencies of these nutrients can reduce the activity of glutathione peroxidase).
Antioxidants are essential for life as our protectors against free radical damage. |
For example, a nutritional antioxidant, such as vitamin C (ascorbate), is of incredible importance here beacuse of its fundamental role in protecting our body against vicious free hydroxy radicals.
Vitamin C can also react effectively, in aqueous solutions such as blood, with free radical oxidants prior to their initiation of oxidative damage to lipids, especially to those within lipoproteins or cell membranes. It simply provides a means to carry the antioxidized free radicals out of the body.
Without the removal of these lipid free radicals, alterations in membrane integrity, potential, and fluidity may occur, with possible membrane rupture and cell death. Here another antioxidant nutrient, vitamin E, is a big help.
Niacin (B3) is another vitamin, which interacts with other nutrients in order to regenerate their antioxidant properties.
Other antioxidant nutrients, such as carotenoids (beta-carotene, lycopene, etc.) possess the ability to react with and inactivate free-radical reactions, either in solution or in membrane systems.
Many studies have provided sufficient evidence, documenting the essential role of antioxidants in the fundamental functions of the body, such as growth, maintenance of health, and metabolism. In light of these studies, many existing official "standards" need to be re-evaluated such as:
- Recommended Dietary Allowances (RDA) and Daily Value (DV) of nutrients
- the concept of prevention of diseases induced by vitamin and mineral deficiencies, and
- the view of optimal levels of nutrients and their role in controlling degenerative diseases, including atherosclerosis.
Due to a close relation between free radical activity and protective function of antioxidants and atherosclerosis, it's said that this degenerative disease can be:
- caused by the absence or deficiency of antioxidants in the body
- prevented by their regular presence in sufficient amounts, and
- reversed by their optimal or optimized supply through specific supplementation.
The existing research indicates that if enough antioxidant protection is available, it will prevent the oxidation of cholesterol from free radicals. Only cholesterol in its oxidized form becomes a risk factor for atherosclerosis - taken up into the arteries, it contributes to the atheromatous plaque formation (Mol Cell Biochem 1992 111;41-7).
Because of their crucial role in the body, antioxidants must be supplied - wholly or partially - first of all, by the diet. Here comes the importance of:
Reverse Atherosclerosis: Targeted Supplementation
Prevention and reduction of endothelial cell injury, or improvement of endothelial function appear to be most important in the process of controlling atherosclerosis. |
- vitamin A
- vitamin C
- beta-carotene (and other carotenoids)
- selenium, and many others (Mol Cell Biochem 1992 111;41-7).
Free radical-induced changes can lead to mutations, even breakages or injuries to the body's cells, which, if not repaired, may result in a variety of serious diseases.
The cardiovascular system is known to be highly susceptible to free radical attack. Especially vulnerable are the endothelial cells in arterial walls. When injured, they trigger the blood platelet accumulation function, in order to protect and, eventually, heal the damaged areas.
However, if free radical injury to the endothelial damage continues, the blood platelet accumulation function becomes, at some point, abnormal and out of control - so to speak, contributing to the progressive process of arterial plaque formation, that is atherosclerosis.
The major constituents of the artery-clogging, atheromatous plaque are
- lipids (fat)
- foam cells (macrophages full of lipid material)
- fatty streaks, and
- plaques in the intima of blood vessels.
In many studies, the risk for the free radical-induced endothelial injury has been strongly correlated with low intake or low nutritional status of antioxidants, such as:
- vitamin A,
- vitamin C,
- beta-carotene (and other carotenoids),
- selenium, and many others (Mol Cell Biochem 1992 111;41-7).
Therefore, the inclusion of antioxidants and enzymes, in form of dietary supplements, can help control abnormal platelet accumulation function by:
There is sufficient research and evidence to confirm that specific nutritional supplements can help
- heal the endothelium and/or the underlying smooth-muscle cells, and
- stop the inflammatory process leading to atherosclerosis.
Clear-G Formula: All-Natural Flow Modulator
Any wound requires more blood than normal in order to heal. If that extra blood is not forthcoming the wound never heals and in fact dies back. |
One of the natural, non-amputation methods to effectively treat dry foot gangrene is the nutritional revasculatization.
Its first and foremost goal is to improve and - over a period of time - restore the impaired circulation in the areas wounded by vascular ischemia (decreased blood flow) - the most common cause of foot ulcers and/or gangrene.
The process of natural revascularization can be triggered with an application of nutritional - natural and essential - factors that - when presented in specific ratios and amounts - are able to correct longer standing deficiencies and imbalances which are known to contribute to the circulatory problems.
As opposed to standard medical methods of treating vascular ischemia, it helps to reduce the impact of factors that created the buildup of atherosclerotic plaque in the arteries.
The nutritional revascularization - natural restoration of blood flow to the arteries - can be done with the help of Gangrene Clear-G Formula - a targeted, orthomolecular formulation providing a comprehensive support for the entire circulatory system.
Simply put, Gangrene Clear-G Formula works to improve circulation. And improved circulation allows the body to "heal itself."
What could be better than a nutritional supplement fixing the impaired circulation that develops in a diseased body?
In many individuals, Gangrene Clear-G Formula has also been able to:
- reduce and stabilize the blood sugars and
- lower insulin requirements better than most prescription drugs.
In our clinical experience, it does help to stop and - over a period of time - reverse the progression of gangrene in a way of
Without improving the flow of blood to the affected limbs - amputation is a futile exercise, although it can be life saving at times. |
- reducing the dysfunction of endothelium - the innermost arterial lining by stimulating the body’s natural built-in, internal free-radical scavenging system
- overcoming peripheral vascular ischemia by improving and/or restoring circulation - blood flow to the wounded areas
- encouraging vasodilatation - widening (dilation) of the lumen of blood vessels
- promoting the body's ability to develop collaterals - new, small blood vessels in the problem areas
- delivering more vital, oxygen-rich and nutrient-dense blood to the affected areas
- producing the growth factors - the necessary for healing substances released by the body into bloodstream and stimulating the growth of tissue and skin
- preventing infection of the gangrenous tissues.
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Continue reading this article... |
Expensive and time-consuming debridements, medications, antibiotics, therapy and skin grafts cannot correct the underlying process which is the impaired blood flow. |
In other words, in dry gangrene the blood flow (circulation) is only partially impaired and the other part (venous system) is still functioning, or ready to function. Therefore, it is able to cooperate by supporting any attempt to restore internally faulty circulation, especially in its arterial part.
The other factor making dry gangrene highly responsive to the nutritional method is the fact that this disease is characterized by a gradual progression.
It means that due to relatively slow development of gangrene, there is enough time to support the body nutritionally in order to restore partially impaired circulation - in this case, to unclog arterial blockages.
These two factors - the partial impairment of the blood flow and the gradual progression of the disease - have been commonly overlooked, not to say ignored, by standard medical treatments of gangrene.
Thermography:
The following thermographic photos are of a 57-year-old man whose feet were thermally "amputated" due to poor circulation.
This man considered himself fairly active and on a good diet. He was on the nutritional revascularization program for six (6) weeks.
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After:
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The follow-up thermographic photo demonstrates a glowing picture of the feet with all toes visible. The increased temperature in this area was made possible by improved circulation (blood flow).
Within six (6) weeks, vascularity in this man's feet was increased by 86 percent, and pulse volume - by 50 percent. Considering the fact that impaired cirulation in the extremities is difficult to treat, to see such a high degree of response in only six weeks is most significant.
Plethysmography:
The following plethysmographs are of both feet of the same 57-year-old man.
The first graph shows the signs of poor circulation, such as decreased size of the waveform, the oval peaking, and the indistinct low volume peaks - prior to the nutritional revascularization program:
The second graph demonstrates the signs of improved circulation, such as increased size of the waveform, the sharper peaking, and the distinct high volume peaks - after six (6) weeks of the nutritional revascularization program:
Within six (6) weeks on the nutritional revascularization program, vascularity in this man's feet was increased by 86 percent, and pulse volume - by 50 percent.
Considering the fact that impaired cirulation in the extremities is difficult to treat, to see such a high degree of response in only six (6) weeks is most significant.
Thermography is a photographic technique that measures and records infrared heat patterns. It can be used to detect areas of poor circulation in the body.
Plethysmography is a technique used to measure blood flow volume in the body. In atherosclerotic or diabetic disease, the vigour of the blood flow is seriously decreased.
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These Stories Speak for Themselves: Testimonials
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Thursday, January 31, 2008
Dear Andrew:
I contacted you last year in early December about my father's condition.
He had undergone 2 different surgeries on his right foot: one to remove the 2 outside toes, and then a year later the 3 middle toes. At that time, they also did a bypass and thought my father would be OK.
He had tried IV chelation a few years ago, and I think that helped him some. Unfortunately, he wasn't able to continue the treatments.
Early December, when gangrene in his right foot set in, my father was getting ready to die. The only option he was given by the doctors was below the knee amputation without any guarantee of success. He turned that down. The surgeon had also told my father that basically all his arteries below his knee were “just hanging there like strings.”
I had read enough even then to know that without treating the underlying problem, at best everything being done was no more than putting a band-aid on a huge problem.
Fortunately, as I was looking for information on managing the pain for gangrene, I ran across your website.
Today, he is still walking OK and there is no smell (only 2 months after the gangrene began to set in). He is relatively pain free and hopeful that he has some time left (he says he is too ornery to die).
When I first spoke with you, you said there was perhaps a 50/50 chance that your Formula would help my father, so he agreed to try it.
As far as I am concerned, if not for your product, he may not have made his 80th birthday earlier this month, or if he had, I don’t think he would have been as relatively pain free and in a good condition as he was.
When I ask him, he comments that he is sleeping well at night, without foot pain waking him up. I know when his toes were gangrenous and pain at night was a big problem for him.
My sister, who does not see him as frequently as I do, also commented that his color was looking better than it has in a long time.
Thank you for your product. I believe that it is responsible for giving my father some additional time with good quality.
I have attached a picture of his foot from the bottom. While I am certainly no expert, it seems to me that the foot is healing. I was even able to remove a large section of dead skin off of the top of the foot this morning and underneath the skin seemed pink and healthy.
I am so thankful for this Formula and plan to share the results my father has had with the podiatrist he had been working with. He works with many diabetic patients and is open to alternative therapies. He might find this interesting.
Thank you again. I'll let you know how things go in the upcoming months.
Karen Gibson
Hermitage, TN
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Wednesday, May 21, 2008
I just wanted to let you know that my dad's foot now appears to be TOTALLY healed.
The 'scab' came off about a week or so ago and the tissue is healthier than it has looked in years. Here are the pictures of his foot as it is now.
I took my father to see his podiatrist last week and he was very happy to see the condition of my father's foot. I brought him an empty jar of your formula.
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Thank you again for the work you have done to create this product!
Karen
P.S. Finding your formula was a specific answer to a specific prayer...
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* The testimonial above is a true, documented story. It has been reviewed, however, it is the sole opinion of the listed individual.
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Read more testimonials... |
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© 2000-2008 Reverse Gangrene.com: Foot Gangrene Controlled Naturally With Gangrene Clearing Clear-G Formula. Stop the Progression of Gangrene: Avoid Toe, Foot or Leg Amputation. All rights reserved worldwide. This document may not be copied in part or full without express written permission from the publisher. The information on gangrene and nutrition provided herein is a general overview on this topic and may not apply to everyone, therefore, it should not be used for diagnosis or treatment of any medical condition. While reasonable effort has been made to ensure the accuracy of the information on reversing dryg foot gangrene naturally, Full of Health assumes no responsibility for errors or omissions, or for damages resulting from use of the gangrene information herein.